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Bhat A, Moglad E, Afzal M, et al

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Biomedicine 6 (1), 28

No effects were seen when glucose was not administered, compatible with the idea that DPP-4 inhibition exerts an anti-hyperglycaemic effect by preventing degradation of endogenously released GLP-1 (26), subsequent studies in glucose-intolerant rodent models did show that the improved glycaemic control following in vivo DPP-4 inhibition was associated with enhanced intact GLP-1 responses to glucose challenges (2729)

8 13 The low prevalence was interpreted as a lag time in translating novel therapies into widespread clinical practice