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In preclinical models of neurodegeneration, GLP-1R agonists reduce amyloid plaque formation, improve neuronal survival, and reduce neuroinflammation

In diabetic neuropathy, microangiopathy damages these vessels, starving nerves of the resources needed for survival and repair

The FDA classifies it as a Category 2 bulk drug substance, noting potential safety concerns in unregulated compounding

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Whereas it is tempting to explain diverging results by referring to different reward phases, there is not enough evidence on reward phase specificity of gastrointestinal hormones yet due to the focus on anticipation

2021;118:e2019388118