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Strother says GLP-1 medications are getting a lot of attention for two reasons
Over the past few years, peptides known as GLP-1 receptor agonists have completely reshaped the weight loss landscape
11, 12 The mechanisms behind these powerful effects are multifactorial, including indirect benefits from weight loss and improved glucose control, as well as more direct actions
Many individuals achieve weight reductions of 15 to 22 percent or more of their starting body weight over the course of treatment
Cardio- and reno-protective effects are unlikely to be solely explained by the mechanisms used by these drugs to lower blood glucose levels, as the same effects are not seen with drugs that have stronger antihyperglycaemic actions [111], and were not dependent upon the degree of HbA1c reduction [113,114,115]
doi: 10.1093/humupd/dmp008 142 MoranLJTassoneECBoyleJBrennanLHarrisonCLHirschbergALet al
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