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Mechanistic work suggests that tri-agonist signaling may influence several components of glucose regulation, including insulin secretion pathways, hepatic glucose handling, and peripheral metabolic signaling

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Describing herself as largely 'the lab rat' when she joined the diabetes team, Knudsen remembers she spent 'the first year in a cold room with three technicians to screen hundreds of thousands of compounds to see if they could wedge into the GLP-1 receptor and other targets of interest just snugly enough to stimulate insulin secretion.' To help speed up the screening process, Knudsen devised a method to test 96 candidates in one go instead of just one

"Buried in Wegovy Costs, North Carolina Will Stop Paying for Obesity Drugs"

doi: 10.1210/jc.2018-00070 28 MarsoSPBainSCConsoliAEliaschewitzFGJodarELeiterLAet al

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