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Demonstrated an acceptable safety profile, with gastrointestinal events being the most frequently reported adverse effects

Metformin Represses Glucose Starvation Induced Autophagic Response in Microvascular Endothelial Cells and Promotes Cell Death

Twice-weekly split dosing divides the full therapeutic weekly dose into two equal injections to smooth plasma levels

Adequate calcium and vitamin D throughout life, as part of a well-balanced diet, may reduce the risk of osteoporosis

However, it's a useful rotation option, especially for patients who experience site-specific reactions

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