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The safety profile showed modestly elevated rates of overall side effects and drug-attributable side effect in the efinopegdutide cohort relative to semaglutide, attributable predominantly to a higher frequency of gastrointestinal manifestations [52]

Lets be direct about what this means for consumers: nobody, not HIMS, not the compounding pharmacy, not the prescribing provider, has any idea what the actual plasma concentration of semaglutide is after a patient takes this pill

It doubles the cost

Eat on a schedule

This is where microdosing GLP-1 agonists presents a compelling alternative

If GLP-1 agents reduce incidence (as observational studies suggest), that may translate into clinically meaningful delay