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The short half-life of native GLP-1, typically only 12 min due to rapid degradation, has facilitated the development of structurally modified GLP-1 analogs with longer half-lives, such as liraglutide, exendin-4, and dulaglutide, which exhibit 97%, 53%, and 90% sequence homology, respectively 12

The researchers also found other papers that cited aspects of the retracted studys methodology, or used the findings as supporting evidence in their introduction and discussion sections, again raising concerns regarding the potential impact of the retracted paper on the research that directly cites it

The extended time at intermediate doses before reaching maximum provides more opportunity for the digestive system to adjust

Kaddurah-Daouk at Duke is PI of the Mood disorder Precision Medicine Consortium (funded by NIMH R01MH108348) and the Alzheimer Gut Microbiome Project (funded by NIA U19AG063744)

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