Bariatric surgery--which seeks to reduce the size of the stomach or bypass part of the GI tract--was conceived in the 1960s when surgeons observed that gastric cancer patients who had part of the stomach removed (subtotal gastrectomy) went on to lose weight
Perry T, Lahiri DK, Sambamurti K, et al
Self-reported titration described in community sources: 0.25 mg 3x/week for week 1, then 0.5 mg 3x/week thereafter, with optional 8-week-on / 8-week-off cycling
Additionally, we systemically estimated the effects of GLP-1R-based agonists on the metabolic risk factors and multiple-organ complications of MASLD, which guide further clinical trials
Because appetite is naturally reduced and individuals feel full faster, the quality of the food consumed becomes exceptionally important
JCI Insight 6 , e153732 (2021)