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Moreover, real-world evidence derived from the US Collaborative Network of TriNetX, which analyzed data from individuals with T2DM aged 18 years who initiated tirzepatide or a GLP-1 RA between June 1, 2022, and June 30, 2023, suggests that tirzepatide reduces the risk of all-cause mortality by 42%, MACE by 20%, and major adverse kidney events by 46% [84]

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