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Patients with BMI 2529 who have metabolic risk factors, prediabetes, or insulin resistance may qualify for compounded therapy

[1] This means patients can use any of the approved sites without needing to adjust their dose or timing

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STATs exhibit compartment-specific effects: nuclear STAT3 promotes autophagy by activating autophagy and lysosomal genes, whereas cytoplasmic and mitochondrial STAT3 inhibit autophagy by repressing the PKR and FOXO pathways

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weight loss market (including GLP-1s) reached an estimated $135 billion in 2025