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Needle depth awareness: Semaglutide pens come pre-set, but ensure you're gently pinching the skin to isolate the subcutaneous fat away from the underlying muscle

If you have specific metabolic concerns, discuss them with your provider in the context of those conditions rather than weight loss

Both semaglutide (as Wegovy) and tirzepatide (as Zepbound) are specifically FDA-approved for weight management in people without diabetes who meet BMI criteria

But it is recommended for a BMI of 27 with a comorbidity, or 30 which is obese, said Pierre

Theres also the question of long-term safety

It mimics the same two hormones as Mounjaro, plus a third hormone, glucagon