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People on retatrutide in clinical trials experienced a decrease in total body fat mass by as much as 26.1%, while others lost up to 6.5 kg of lean mass

Retatrutide also demonstrated clinically meaningful improvements in cardiometabolic markers, including systolic blood pressure, nonhigh-density lipoprotein cholesterol, and triglycerides

Kidney Failure Research indicates that in some cases, use of semaglutide contributes to kidney disease

For appetite suppression and weight loss, the timeline differs somewhat

Alternatively, participants could also be enrolled if they were aged 60 years or older and had cardiovascular risk factors

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