The slightly greater HMOX1 induction by heme compared with heme-HPX is because the rate of heme diffusion into cells is significantly faster than the gradual, relatively slow and safe heme delivery via heme-HPX endocytosis (Smith and Morgan, 1981)
Nature 444 (7122), 10271031 (2006)
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Improved Metabolic Health : Patients often see enhanced blood sugar control, decreased blood pressure, and better cholesterol profiles
That difference may also influence the prevalence and severity of side effects
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