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In human umbilical vein endothelial cells (HUVECs) and aortas from ApoE -/- mice, TMAO increased the concentrations of reactive oxygen species (ROS), especially superoxide, by inhibiting the SIRT3-SOD2-mitochondrial ROS signaling pathway (75)

Indian J Exp Biol 40(11):1233 Jones DP (2008) Radical-free biology of oxidative stress

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