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Abbreviations CVD: Cardiovascular disease T2D: Type 2 diabetes CV: Cardiovascular HF: Heart failure GLP-1RA: Glucagon-like peptide 1 receptor agonist SGLT-2: Sodium-glucose cotransporter 2 MACE: Major cardiovascular events MI: Myocardial infarction ADA: American Diabetes Association HFrEF: Heart failure with reduced ejection fraction HFpEF: Heart failure with preserved ejection fraction FDA: Food and Drug Administration NHANES: National Health and Nutrition Examination Survey CKD: Chronic kidney disease References Grundy SM, Benjamin IJ, Burke GL, et al

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*As above

Oral semaglutide (now FDA-approved for weight management in 2026) provides appetite suppression but with somewhat lower bioavailability than the injectable

without a plan, some people can lose muscle along with fat

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