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Several studies have proposed mechanisms underlying the effect of IF on mitochondrial health

It has been demonstrated that loss of PINK1 function leads to increased formation of CISD1 dimers, which are unable to coordinate iron-sulfur clusters and thus impair iron metabolism (173)

-Lipoic acid attenuates oxidative stress and neurotoxicity via the ERK/Akt-dependent pathway in the mutant hSOD1 related Drosophila model and the NSC34 cell line of amyotrophic lateral sclerosis

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