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Doppler ultrasound examination of the thyroid may be helpful in differentiating among the various causes of thyrotoxicosis

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Twin, family and adoption studies have consistently demonstrated that genetic factors influence the variation in body weight seen in an obesogenic environment 4

Keywords: vitamin B-12, folic acid, folate, holotranscobalamin, homocysteine, methylmalonic acid, pernicious anemia Statement of Significance : There is significant circumstantial evidence that excess folic acid consumption exacerbates vitamin B-12 insufficiency, but a biochemical/physiological mechanism has not yet been identified

Studies show L-citrulline raises plasma arginine and nitric oxide levels more effectively, improving blood flow and endurance

The realisation is that these gamechanger drugs are now making weight loss even easier, but as always our focus should be on the major challenge of weight maintenance