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When B12 levels fall below optimal ranges, the integrity of this myelin sheath can become compromised, potentially leading to nerve damage known as peripheral neuropathy

Adenosine A2A receptors control glutamatergic synaptic plasticity in fast spiking interneurons of the prefrontal cortex

PMID: 9005976

The ability of glutamate to improve intestinal barrier function is also demonstrated in a study using adult human IEC lines, where glutamate addition significantly reduced phorbol-induced hyperpermeability (133)

PMID: 8882911 Edwards R, Peet M, Shay J, Horrobin D (1998) Omega-3 polyunsaturated fatty acid levels in the diet and in red blood cell membranes of depressed patients