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Compared with GPX1-3, GPX4 is also involved in the reduction of complex membrane-associated phospholipid hydroperoxides such as phosphatidylcholine hydroperoxide and cholesterol hydroperoxide, in addition to reacting with soluble, low molecular weight hydroperoxides such as t-butyl hydroperoxide and cumene hydroperoxide [68]

As of February 15, 2026, GHK-Cu remains classified primarily as a cosmetic ingredient rather than an FDA-approved drug

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Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity

Catelas et al., 2020)

Leonard Guarente, an M.I.T