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Abstract Asthma, which affects some 300 million people worldwide and caused 455,000 deaths in 2019, is a significant burden to suffers and to society

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Genetic deficiencies in the POMC-MC4R pathway leads to severe infantile obesity [5, 6]

The first and rate-limiting step, catalyzed by glutamate-cysteine ligase (GCL), generates -glutamylcysteine from glutamate and cysteine

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This suggests that B12 indeed affects the circadian clock