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To determine whether these effects depend on RAMP-containing amylin receptor subtypes (AMY1R and AMY3R), experiments were conducted in HFD-fed WT and RAMP1/3 double knockout (KO) mice

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The main characteristic of PD is the reduction or disappearance of dopaminergic neurons in the substantia nigra (SN), with the depletion of dopamine in the striatum and the emergence of Lewy bodies with -synuclein aggregation as main components

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