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Albiglutide (GlaxoSmithKline) is a fusion of two GLP-1 molecules with human albumin, which increases the proteolytic stability of GLP-1 and slows renal clearance, extending the half-life to 120 h

Although increasing fertility isnt their intended purpose, Ozempic/Wegovy and Mounjaro/Zepbound appear to result in women getting pregnant more easily

thus, only ~12% of gut-derived GLP-1 enters the systemic circulation intact 121,122,123

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Example going the other direction: You currently inject on Mondays

And preclinical models consistently show benefits for Alzheimers-like pathology. In addition, a combination of their anti-inflammatory effects and effects on the vasculature likely explain some of the beneficial effects on dementia reported in observational studies, Holst says