Drug/Laboratory Test Interactions Persons taking most antibiotics, methotrexate and pyrimethamine invalidate folic acid and vitamin B12 diagnostic blood assays
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The Kennel Club
10.1097/00006534-200005000-00019 [DOI] [PubMed] [Google Scholar] Numata Y., Terui T., Okuyama R., Hirasawa N., Sugiura Y., Miyoshi I., et al
In the analyzed samples the average content of the analytes of interest amounted to 185.2 42.6 nmol/mL for Cys, 7.2 4.4 nmol/mL for Hcy, 5.4 3.5 nmol/mL for GSH and 0.92 0.7 nmol/mL for N-Hcy-Lys
Despite employing conservative assumptions in this work, the primary source of uncertainty stems from the absence of any formal guidance on the parameterization of these models and validation data, unlike the well-established validation of physiologically based kinetic models against human clinical data (Li et al., 2021