For example, while luminal or vascular administration of butyrate during an isolated perfused colon study increased GLP-1 and PYY secretion 93 , only vascular administration of acetate induced GLP-1 and PYY secretion, with luminal acetate inducing only GLP-1 secretion 93
Since GLP-1RAs reduce circulating cholesterol and alter systemic lipid flux, downstream effects on membrane-associated redox buffering are biologically plausible, although direct clinical evidence remains limited
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however, neither guanosine triphosphate (GTP) levels nor tissue methylation activity were significantly changed
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