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In this context, the present work evaluated the applicability of the commercially available upper MucilAir-HF and lower EpiAlveolar human lung models to be used as in vitro systems within a NAM toolbox to identify the bioactivity (i.e., in vitro PoD derivation) and risk of materials that may reach the respiratory tract and induce lung toxicity

During sepsis, the body is in a state of stress, with elevated blood glucose levels and increased ROS levels (88,89,151)

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