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It cites a journal finding that peptide-based compounds lose potency faster at room temperature, though it does not identify the specific study

The recommendation may become relevant to individualized compounding if FDA acts, but it is not proof that KPV treats inflammatory bowel disease, skin disease, or other conditions

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The majority of the published literature examines each compound independently, and the synergy hypothesis, while mechanistically well-supported, has not yet been the subject of large-scale controlled studies