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The paucity of well-controlled clinical studies complicates the confirmation of whether the mechanisms identified in animals are directly applicable to humans

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These effects are linked to its ability to normalize nitric oxide production, regulate oxidative balance, and maintain microvascular integrity across multiple tissues

Low serotonin levels can lead to depression, so getting enough vitamin B12 can improve mood and possibly minimize depressive symptoms

doi: 10.1159/000320773 142 ShinozakiSChangKSakaiMShimizuNYamadaMTanakaTet al