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Zareba P, Colaci DS, Afeiche M, et al

Steps to Take If Freezing Is Suspected If there is any doubt about whether tirzepatide was frozen, the pen should be thrown away

Further study is required to interpret these observations

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[9] [10] However, older adults with severe heart failure or significant renal impairment require careful assessment, as dehydration from gastrointestinal side effects may exacerbate kidney function decline and increase acute kidney injury risk