Efficacy of Cichorium intybus on alanine aminotransferase in nonalcoholic fatty liver disease: a randomised double-blind clinical trial with placebo
The mechanisms include reduction of excitotoxicity and oxidative stress, enhanced neurotrophic factor expression supporting neuronal survival, angiogenesis improving cerebral blood flow, and modulation of dopamine and serotonin systems
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Concretely, GPX4 uses GSH as the substrate to reduce phospholipid hydroperoxides (PLOOHs) to hydroxyl derivatives (PLOHs), and oxidizes GSH to GSSH, therefore alleviating the damage of oxidative stress to tumor cells (Stockwell, 2022)
In humans, it exerts a broad range of physiologic effects when ingested orally