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Sasaoka T, Ishiki M, Wada T, Hori H, Hirai H, Haruta T, Ishihara H, Kobayashi M (2001) Tyrosine phosphorylation-dependent and -independent role of Shc in the regulation of IGF-1-induced mitogenesis and glycogen synthesis

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In summary, nanoparticles can also directly regulate immune cells in the tumor microenvironment by activating the NF-B or mTOR pathways, as well as by inhibiting SHP2, CD73, or glutaminase

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