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In clinical trials, individuals with obesity or overweight saw substantial weight loss, with some losing 15-20% of their body weight

Both Nreu et al

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It also matters if you have surgery planned or severe GI symptoms

Sepesi B, Schmidt HE, Lada M, Correa A, Walsh GL, Mehran RJ, Rice DC, Roth JA, Vaporciyan AA, Ajani JA, Watson TJ, Swisher SG , Low DE, Hofstetter WL

World J Gastroenterol 14(2):193 Alkhouri N, Carter-Kent C, Feldstein AE (2011) Apoptosis in nonalcoholic fatty liver disease: diagnostic and therapeutic implications