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In addition, GSTs are also involved in conferring multidrug resistance with a non-catalytic mechanism through their inhibition of the JNK signaling pathway, an event that protects tumoral cells from apoptosis, as it will be detailed later

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Understanding these pathways helps explain why the peptide shows such broad therapeutic potential across different tissue types

This intrinsic capability suggests considerable potential for leveraging EVs to deliver vitamin D or its bioactive derivatives specifically to neural targets, offering a novel strategy to mitigate cognitive decline [139]

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