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Mild irritation: redness, dryness, or itching at the application site

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In rats, intraperitoneal injection of 2.5 mg CGN every 2 days for a week, followed by intraperitoneal injection of antigens (lipopolysaccharide [LPS] or sheep red blood cells [SRBC]) resulted in decreased immune response to LPS (90% inhibited) and SRBC (20% inhibited) as assessed by anti-LPS and anti-SRBC plaque forming cells in the spleen (Janezic, Mostarcia-Stojkovic, and Lukic 1979 Janezic, A., M