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Women with PCOS face elevated risks of developing type 2 diabetes mellitus, with studies suggesting a two- to four-fold increased risk compared to women without the condition
[14] Small clinical trials indicate that maternal supplementation of 4,000 IU day or staggered 50,000 IU oral doses can safely maintain 25-hydroxyvitamin D above 30 ng mL without inducing hypercalcaemia, whereas single injections of 300,000 IU are reserved for severe malabsorption emergencies when benefits outweigh theoretical teratogenic risk
GLP-1 medications can produce a 10-20% body weight reduction in many patients (ref), which can reduce the excess tissue mass that collapses the airway and causes OSA
This insulinotropic and glucagonstatic molecule is well-tolerated and can be categorized into two groups according to the actions it promotes: short-acting compounds that deliver short-lived receptor activation and long-acting compounds that activate GLP-1 receptors continuously
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