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The increased energy expenditure from glucagon receptor activation means your body burns more calories even at rest, which could be particularly beneficial for those with PCOS who often have metabolic rates that feel stubbornly slow

Morning injection also aligns with natural cortisol patterns

The standard dose is 2mg daily, with some protocols using 1-1.5mg for smaller individuals or those experiencing side effects

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Retatrutide stands out from other GLP-1s as it works on three hormone receptors instead of just one (Semaglutide/WeGovy) or two (Tirzepatide/Mounjaro & Zepbound)