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One-third of all drugs and drug candidates are excreted unchanged from the body by the kidneys, and drug-induced nephrotoxicity accounts for 20% of all episodes that lead to acute kidney failure (Naughton 2008b)

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Optimal neuroprotection is observed at ~10 mM, with concentrations below this threshold insufficient to alleviate the metabolic crisis associated with cerebral ischemia (160)

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