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PMID 18950853), randomized 203 obese patients to receive tesofensine 0.25 mg, 0.5 mg, or 1.0 mg daily, or placebo, for 24 weeks

UPR does this by activating three ER transmembrane sensors, inositol-requiring enzyme 1 (IRE1), protein kinase RNA-like endoplasmic reticulum kinase (PERK) and activating transcription factor 6 (ATF6)

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