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It has been postulated that the rapid reduction in blood glucose levels triggered by GLP-1 RAs leads to a hypoxic state of the retina that promotes further abnormal angiogenesis, Reut Shor , MD , of the department of ophthalmology and vision sciences at the University of Toronto, and colleagues wrote

Its convenient, but absorption varies between people

When these melanocytes start producing more melanin, then your skin starts getting darker and when the melanin production starts reducing, your skin tone starts lightening