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GHK-Cu appears to reset this decline by upregulating the transcription factors that drive fibroblast proliferation

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This cascade leads to ferroptosis, contributing to neuronal death (59)

A 2023 meta-analysis of 26 randomized controlled trials (1,721 participants) found hydrolyzed collagen significantly improved skin hydration and elasticity versus placebo, with benefits typically appearing after 812 weeks of daily use