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Aspulvinone O, a natural inhibitor of GOT1 suppresses pancreatic ductal adenocarcinoma cells growth by interfering glutamine metabolism

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[DOI] [PMC free article] [PubMed] [Google Scholar] Zentgraf U, Andrade-Galan AG, Bieker S

For example, studies using rodents and primary neuron cultures have demonstrated that sulforaphane upregulates key antioxidant enzymes, such as glutathione-S-transferase (GST), NAD(P)H oxidoreductase 1 (NQO1), and heme oxygenase-1 (HO-1), leading to reduced oxidative burden in both neurodevelopmental and neurodegenerative models (Innamorato et al., 2008

The cells in the stomach wall secreted an other enzyme, known as antipepsin, which should prevent auto digestion