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The glucose-dependence that makes them safe, the central action that drives weight loss, the cardiovascular and renal benefits, and the gastrointestinal side effects all trace back to where the receptor sits and how it signals

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Try a different medication: If you want to keep taking a weight-loss medication but the cost or side effects make GLP-1s a no-go, there are other options out there such as Qsymia and Contrave and your clinician may be able to recommend and prescribe a different weight-loss medication

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