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PubMed / Current Pharmaceutical Design

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You can take it with food or without food

However, for people with G6PD deficiency, sulfa drugs can be a significant trigger for hemolysis

Transdermal estradiol had no effect

Because the body does not store riboflavin, any extra that is taken in beyond what the tissues need or what the kidneys can reabsorb is flushed out in the urine as riboflavin or metabolites, such as lumiflavin, 7-alpha-hydroxy riboflavin, and 10-hydroxyethylflavin [47]