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This review discusses the downregulation of VD-metabolizing genes needed to convert consumed VD into 25(OH)VD to enable its metabolic action exhibited by subjects with metabolic syndrome, obesity, and other chronic diseases

Dupont et al

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Arterioscler Thromb Vasc Biol 34:751758 Nishizawa H, Matsumoto M, Chen G, Ishii Y, Tada K, Onodera M, Kato H, Muto A, Tanaka K, Igarashi K (2021) Lipid peroxidation and the subsequent cell death transmitting from ferroptotic cells to neighboring cells

Jumping straight to 1.0 mg daily rarely produces better results than standard dosing and may increase the likelihood of mild side effects

10.1111/andr.13461 85 LiD.LiJ.JiaB.WangY.ZhangJ.LiuG