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Let's look at how that translates to dosing with a U-100 syringe: 5mg is in 100 units (1 mL) 1mg is in 20 units (0.2 mL) 0.5mg is in 10 units (0.1 mL) As you can see, a 1mg dose now requires twice the volume (20 units instead of 10)

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