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Gastrointestinal effects The most common side effects are gastrointestinal, driven primarily by the GLP-1 mediated slowing of gastric emptying

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In knee OA, clinical data suggest that GLP-1RAs improve pain and function and reduce the risk of surgical intervention

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Alterations in metabolite production in the gut, from either host or microbiota or their interaction, may be related to the manifestation of IBS symptoms