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Although the liver, with its high mitochondrial content, is the primary organ affected by acetaminophen poisoning, other high-energy organs are also at risk with regular APAP use

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The Exercise in Left Ventricular Dysfunction (ELVD) trial evaluated efficacy of exercise in patients with a first Q wave MI and a left ventricular ejection fraction (LVEF) below 40% and the results indicated that AET improved the quality of life of patients (Giannuzzi et al., 1997)

doi: 10.1152/ajpendo.1995.268.6.E1192