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Pregnant subjects should also avoid semaglutide, based on animal studies that reveal GLP-1-RAs could reduce embryo size and cause developmental abnormalities [35]

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In pharmacology trials, GLP-1RA treatment has been shown to delay gastric emptying within the first postprandial hour [25, 28], although overall gastric emptying did not appear to be affected [28], suggesting additional mechanisms of action in GLP-1RA-mediated weight loss