The liver processes toxins, heavy metals, metabolic waste, and pharmaceutical drugs through two primary phases
Therefore the overall impact on fertility that ROS has is not a matter of if it is there or not (as mentioned earlier, some oxidative stress is required for various reproductive physiological functions), but when levels of ROS are too high (or antioxidant levels are too low) it becomes pathological to sperm and the ability to get pregnant
Randomized controlled trial of oral glutathione supplementation on body stores of glutathione PubMed Ballatori N, Krance SM, Marchan R, Hammond CL
Long-term glutathione supplementation has been shown to lower zinc levels in some cases, but this can be easily countered by increasing dietary zinc or through supplementation
10.1152/ajpgi.1997.273.1.G7 Am J Physiol Gastrointest Liver Physiol
Thus, GSH has been shown to be an effective supplement that can improve glycemic control and reduce oxidative stress in diabetic patients, especially among the elderly